2 edition of Computer modelling of human carbonic anhydrase II. found in the catalog.
Computer modelling of human carbonic anhydrase II.
Nicholas Richard Jones
Thesis (M.Sc.), - University of Manchester, Department of Chemistry.
|Contributions||University of Manchester. Department of Chemistry.|
|The Physical Object|
|Number of Pages||101|
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric s: CA12, CAXII, HsT, CA-XII, . Ethoxyzolamide is a cell-permeant sulfonamide inhibitor of carbonic anhydrase activity (8, 26). If CAH1 enhances carbon assimilation through its carbonic anhydrase activity, we predicted that treatment of cells with ethoxyzolamide would cause defects in photosynthetic carbon assimilation similar to those seen in the cah1 by:
View protein in InterPro IPR Alpha_CA_VII IPR CA_dom IPR CA_dom_sf IPR Carbonic_anhydrase_a-class IPR Carbonic_anhydrase_a-class_CS: PANTHER i: PTHR PTHR, 1 hit: Pfam i: View protein in Pfam PF Carb_anhydrase, 1 hit. A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC ). The human (h) isoforms hCA II, VII, and IX were inhibited in the low nanomolar or subnanomolar Cited by: 3.
Ribbon diagram of human carbonic anhydrase II, with zinc ion visible in the center. The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions).BRENDA: BRENDA entry. Chapter 1: Human carbonic anhydrase II and enzyme modelling 15 Reaction and function 15 Structure 17 Significance of pK a within the active site 21 Deep water molecule and water network 26 His and the proton shuttle mechanism 26 Mechanism of .
The Agamemnon of Æschylus.
Depositional systems and karst geology of the Ellenburger Group (Lower Ordovician), subsurface west Texas
The budget, part II, recommendations for executive, legislative, and judicial salaries
Z80 assembly language programming
Social approaches to mental patient care
Secrecy and silence in the research process
Terebratulacea (Brachiopoda), Triassic to Recent
Iowa Rural and Urban Volunteer Senior Aides Project
Duplication in the Navys management information systems is costly
Night on the island
Medium aevum monographs
An interactive human carbonic anhydrase-II (hCA-II) receptor--pharmacophore molecular model & anti-convulsant activity of the designed and synthesized 5-amino-1,3,4-thiadiazolethiol conjugated imine derivatives. Yusuf M(1), Khan RA, Khan M, Ahmed by: The development of efficient biocatalysts for industry remains a challenge.
Over the past decade, the group of Professor Thomas R. Ward (University of Basel, Switzerland) has developed various artificial metalloenzymes for enantioselective catalysis.
For this purpose, a biotinylated organometallic catalyst is incorporated in (Strept)avidin, thereby providing a hybrid catalyst Author: Fabien Monnard. Subnanomolar Inhibitors from Computer Screening: A Model Study Using Human Carbonic Anhydrase II Grueneberg, S., Wendt, B., Klebe, G.
() Angew Chem Int Ed Engl Cited by: Request PDF | Subnanomolar Inhibitors from Computer Screening: A Model Study Using Human Carbonic Anhydrase II | FlexX and DrugScore are the two computer programs which were applied finally to.
Using Covalent Dimers of Human Carbonic Anhydrase II To Model Bivalency in Immunoglobulins Eric T. Mack, Phillip W. Snyder, Raquel Perez-Castillejos, and George M. Whitesides * Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MassachusettsUnited States.
Folding and Stability of the N-Terminus of Human Carbonic Anhydrase IICited by: Keywords:Carbonic anhydrase, Balaban indices, QSAR, topological index, quantum-theoritical descriptor, human CA II. Abstract: Mathematical models were developed for the estimation of human carbonic anhydrase (CA) II inhibition.
A large set of 95 CA inhibitors incorporating diverse aromatic rings were used for this by: 2. [Show full abstract] rigidity of human carbonic anhydrase II (HCA II; EC ) via incorporation of proline residues at positions and.
A potential function was generated from these observations and used to evaluate models for novel disulfide bonds in human carbonic anhydrase II (HCAII). Three double-cysteine variants of HCAII were purified and the effective concentrations of their thiol groups were determined by titrations with glutathione and by: DFT-Based QSAR Modelling of Inhibitory Activity of Coumarins and Sulfocoumarins on Carbonic Anhydrase (CA) Isoforms (CA I and CA II) Author(s): Erol Eroglu*.
Department of Mathematics and Sciences Education, Faculty of Education, Akdeniz University, Dumlupınar Bulvarı, KampusAntalya, TurkeyCited by: 1. 1KWQ: HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR A new strategy is described to search for possible leads of human carbonic anhydrase II, applying a protocol of several consecutive hierarchical filters involving a preselection based on functional group requirements and fast pharmacophore matching.
A Model Study Using Cited by: “Using Covalent Dimers of Human Carbonic Anhydrase II to Model Bivalency in Immunoglubulins.” J.
Amer. Chem. Soc.,Pp. Using Covalent Dimers of Human Carbonic Anhydrase II to Model Bivalency in Immunoglubulins |. About this book. Introduction. Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer.
Fragment screening is a powerful tool to identify and characterize binding pockets in proteins. We herein present the results of a proof-of-concept screening campaign of a versatile entry fragment library from our laboratory against the drug target and model protein human carbonic anhydrase II.
The screening revealed a novel chemotype for carbonic anhydrase inhibition. “ Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein-Ligand Binding.” Chemical Reviews,Pp.
pdf Function of Carbonic Anhydrase •The carbonic anhydrases (CA) form a family of enzymes that catalyze: •The transport of CO 2 around the respiratory system is vital, however the solubility of CO 2 in water at physiological conditions is very small •Carbonic anhydrase enhances the solubility of CO 2 by catalyzing its conversion to the more soluble HCOFile Size: 1MB.
The theoretical models had good reliability (R 2 >) and predictability (Q 2 >), and the contour maps could graphically present the contributions of the force fields for activity and identify the structural divergence between human carbonic anhydrase II inhibitors and human carbonic anhydrase IX inhibitors.
Consequently, we explored the Cited by: 1. Key Features. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts. Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes.
Identifies new targets for drug design. Carbonic anhydrases have been found in all kingdoms of life. Carbonic anhydrase has 3 different classes: alpha, beta and gamma which share very little sequence or structural similarity, thus far they all perform the same function and require a zinc ion at the active site.
Mammalian carbonic anhydrase is monomeric and belongs to the alpha class. Molecular dynamics (MD) simulations, in combination with the Markov-state model (MSM), were applied to probe CO 2 diffusion from an aqueous solution into the active site of human carbonic anhydrase II (hCA-II), an enzyme useful for enhanced CO 2 capture and utilization.
The diffusion process in the hydrophobic pocket of hCA-II was illustrated in terms of a two-dimensional free. Carbonic Anhydrase II. Carbonic anhydrases form a family of enzymes classified as metalloproteases, because their active site contains a zinc ion and is able to catalyze the reversible hydration of carbon dioxide to generate a proton and a bicarbonate ion.
Carbonic anhydrase II (CAII) is the only soluble form of the enzyme and regulates the acid–base. The approach of CO2 to a series of active site model complexes of human carbonic anhydrase II (HCAII) and its catalytic hydration to bicarbonate anion have been investigated using semiempirical MO theory (AM1).
The results show that direct nucleophilic attack of zinc-bound hydroxide to the substrate carbon occurs in each model by: Human Carbonic Anhydrase.
Product # Description. Add to Cart. C Carbonic Anhydrase II human recombinant, expressed in E. coli, buffered aqueous solution: pricing. C Carbonic Anhydrase I from human erythrocytes: pricing.
C Carbonic Anhydrase I from human erythrocytes Isoelectric focusing marker, pI